Staff Scientist Position
Solid State Pharma Inc. is a leader in the delivery of crystallization engineering services including screening and selection of polymorphs, co-crystals, salts, and crystallization process development and optimization. SPPI has experienced great success with the workflows that have been developed by combining fundamentals of crystallization and solid form science with years of experience and high throughput techniques. SSPI is conducting research on pharmaceutical crystallization engineering, polymorph screening, salt screening, co-crystal screening, chiral resolution, polymorph quantification, converting amorphous material to crystalline solid, chemical and crystallization process modeling.
“Staff Scientist” position is a key contributor to the ongoing research at SSPI reporting to senior scientist or director. “Staff Scientist” will contribute through designing and conducting solid form screening experiments, characterizing the resulting materials, designing and performing crystallization process development for active pharmaceutical ingredients and natural products through utilizing crystallization engineering knowledge and hands on experience. It is expected to have 70-80% lab work.
- Design and perform high throughput polymorph screening, salt screening, solubility measurement and characterization independently
- Design and perform crystallization process development, independently, to achieve desired polymorph and specifications while meeting the specs
- Characterize the generated samples using X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Thermal Gravimetry Analysis (TGA), Liquid Nuclear Magnetic Resonance (NMR), dynamic vapor sorption (DVS), Optical Microscope, Scanning Electron Microscope (SEM), Particle Size Analyzer and HPLC
- Record all the details of experiments and analytical data
- Analyze data that are obtained from experiments and draw conclusions
- Use Deign of Experiment (DOE) software to perform statistical analysis of generated experimental data
- Assists in the evaluation and implementation of new technologies and instruments
- Write high quality weekly and final reports
- Routinely present the project results to the team through teleconference
- Follow the safety rules and housekeeping principles to maintain the working around clean and safe
- Other responsibilities as assigned
Education & Experience
PhD or MSc in chemistry, chemical Engineering or related in the areas of crystallization engineering, solid state characterization or organic chemistry. Previous research experience in crystallization science and engineering is a must. Experience with high throughput or combinatorial experimentation is a plus. Required related experience for PhD is 0-2 years and for MSc is 2-5 years.
- Excellent communication skills and the ability to present the result is must
- Laboratory techniques for conducting wet chemistry experiments
- Knowledge of XRPD, DSC, TGA, STDA, SEM, DVS, NMR, HPLC and particle size analyzer is a plus
- Knowledge of crystallization engineering and solid form screening principles is a must
- Knowledge of Process Analytical Technologies (PAT) tools is a plus. Specifically, FBRM, React-IR and PVM
- Knowledge of statistical Design of Experiment (DOE) is a must
- Experience with DOE software, e.g. Design Expert is a plus
- Ability to use Microsoft office software is a must
While performing the responsibilities of the job, the employee is required to talk, hear, see, stand, walk, sit, smell and use hands and fingers, to handle or feel. The employee is occasionally required to pick up ordinary weights.
Open till filled