NeuroQuest Inc. (www.neuroquest.ca), is a drug development company seeking new approaches to modulation of nerve transmission and promising clinical applications particularly for neuropathic pain. NeuroQuest focuses on a first-in-class small molecule drug discovery platform that is based on bioactives discovered in plant extracts showing efficacy for neuropathic pain. This is an unusually novel and promising opportunity which focuses on the synthesis of a novel class of analgesics by highly competent and experienced research team.

NeuroQuest has entered into a joint venture with Concept2clinic.com, a highly qualified pharmaceutical development team with expertise and lab facilities located in Toronto, Canada.  Expertise exists in all aspects of drug development, from lead chemistry development to clinical research, regulatory affairs and commercialization.  These experts have successfully brought many innovative drug products into market such as Prozac, Lexiva, Symbyax, Strattera, Effient, Byetta, Meloxicam.

NeuroQuest is pursuing a dual-track of market entry for nerve pain products, pursuing a natural health product in Canada and Asia, and a prescription-status product for the US and other markets.  These products promise to be fast-acting, safe, effective, non-numbing and non-burning, unlike current market offerings.

NeuroQuest Inc. is also offering synthetic chemistry, medicinal chemistry, fine chemical production and neurological assay services to the research and biopharmaceutical industry.

These services include:

Synthesis Group

  • Synthesis of intermediates from milligram to gram scale quantities
  • Designing of Synthetic routes and Synthetic route optimization
  • Synthesis of focussed library for in vitro screening

Medicinal Chemistry Group

  • Structure based design, fragment based design and HTS Hit analysis
  • In silico modeling supporting structure based design & SAR (2D/3D QSAR)
  • Synthesis of focussed library, SAR and ADMET optimization
  • IP protection around NCE’s

Neurology Assays

  • Electrophysiology (DRG patch clamp, state dependency, Nav selectivity)
  • Nav subtype selectivity
  • Transient Receptor Potential Channel (TRP) activity assay (HEK cell)
  • Zebrafish Neuroactive Assay
  • hERG Assay

These services include NMR and GC-LC-Mass Spec analysis, including compound identification whether obtained from natural sources or designed and produced by synthesis.  NeuroQuest’s fine chemical services include the ability to solve complex chemical problems.  The company can custom manufacture novel building blocks or scaffolds, intermediates or other fine chemicals.  NeuroQuest has expertise in phytosterols and other related plant derived bioactives.  Download Services PDF file.

NeuroQuest works closely with its sister company CNS CRO (www.cnscro.com), which offers a wide range of animal models as a contract service.  The combined expertise makes both companies leaders in pre-clinical contract research for neurological conditions.

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Both NeuroQuest and CNS CRO are subsidiaries of Neurodyn Life Sciences Inc. (www.neurodyn.ca), a Canadian biotechnology company developing both prescription drugs and natural products for the early stage treatment of neurological diseases.

For more information, contact:

Dr. Alexander McLellan
902-402-1775 (mobile)
mclellan@neuroquest.ca

Mr. Robert Cervelli
902-222-4391 (mobile)             
cervelli@neuroquest.ca

NeuroQuest Inc., Suite 365, 1411 Oxford Street, Halifax, NS B3H 3Z1

Download NeuroQuest’s Synthetic and Medicinal Chemistry Services information sheet